KAI1 gene is differently expressed in papillary and pancreatic cancer: Influence on metastasis
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منابع مشابه
KAI1 metastasis suppressor protein in cervical cancer.
We are very pleased to hear of the molecular abnormalities in two new pancreatoblastomas of Kerr et al. In our recent study of nine pancreatoblastomas, allelic loss on chromosome 11p15.5 was present in 6 of 7 informative cases (86%), and mutations in the APC/ -catenin pathway in 6 of 9 cases (67%). These findings underscore the clinical association between pancreatoblastoma formation and Beckwi...
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KAI1 is a metastasis suppressor gene for prostate cancer that is located on chromosome 11p11.2-13. Using Northern blot analysis and in situ hybridization, we studied expression of KAI1 mRNA in specimens from 14 normal pancreases and 27 primary pancreatic cancers, and then correlated the findings with the clinical and histopathological parameters of the patients. Northern blot analysis showed in...
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We examined 2 normal pancreata, 21 primary pancreatic ductal cancers, and 19 pancreatic cancer cell lines for Fhit expression and FHIT gene status. The normal pancreas expressed Fhit protein in the cytoplasm of ductular cells, whereas interlobular and larger ducts, acini, and insulae of Langerhans were negative. Fhit protein was detected by immunoblot assay in 11 pancreatic cancer cell lines; o...
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The aim of the present study was to investigate the effects of PTEN and KAI1 gene overexpression on the proliferation, metastasis and radiosensitivity of ASPC‑1 pancreatic cancer cells under hypoxic conditions. Recombinant vectors that overexpress PTEN and KAI1 genes were transfected into hypoxic ASPC‑1 cells. Protein expression levels were detected by western blot analysis. An MTT cell growth ...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2000
ISSN: 1007-9327
DOI: 10.3748/wjg.v6.i6.866